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Scientific Programme

Book of abstracts

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Book of abstract

Scientific Programme

Day 1 - Tuesday, 11 June 2019

Aula,  Main building
15:00   Registration at the venue
University of Debrecen, Aula
17:30   Welcome
Beáta Lontay, Chairman of the LOC

Conference opening
László Mátyus, Dean of the Faculty of Medicine, University of Debrecen

Beáta Vértessy, Chair of the FEBS Advanced Courses Committee

Session 1: Keynote Lecture
Chair: Viktor Dombradi
17:45 KL1 Interplay between RabGTPases and the LRRK2 Parkinson’s disease protein kinase
Dario Alessi (University Dundee, School of Life Sciences, Dundee, United Kingdom)
19:00 - 22:00   Welcome dinner
Cour d'Honneur, Main Building of the University of Debrecen

Day 2 - Wednesday, 12 June 2019

Life Science building

8:00 –   Registration at the venue
University of Debrecen, Life Science building
Session 2: Structural insights into protein phosphatases
Chair: Maja Köhn
9:00 – 9:25 IT1 Regulation of protein phosphatase-1 and -2A by small molecules
Ferenc Erdődi (University of Debrecen, Debrecen, Hungary)
9:25 – 9:50 IT2 The PPP regulatory code
Rebecca Page (University of Arizona, Tucson, United States)
9:50 – 10:05 ST1 Determinants of substrate recognition by Phactr1:PP1 phosphatase complex
Stephane Mouilleron (The Francis CRICK Institute, London, United Kingdom)
10:05 – 10:30 IT3 Understanding regulation and substrate specificity of protein phosphatases
Wolfgang Peti (University of Arizona, Tucson, United States)
10:30 – 11:10   Coffee Break
Session 3: Emerging functions of protein phosphatases
Chair: Ari Elson
11:10 – 11:35 IT4 Revealing and inhibiting calcineurin phosphatase function with Short Linear Motifs
Martha Cyert (Stanford University, CA, United States)
11:35 – 12:00 IT5 Phosphoregulation of circadian rhythms
David Virshup (Duke NUS Medical School, Singapore)
12:00 – 12:25 IT6 Regulation of osteoclasts and bone resorption by PTPS
Ari Elson (Weitzman Institute, Rehovot, Israel)
12:25 – 12:50 IT7 Molecular and cellular links between obesity and diabetes
Roberto Coppari (University of Geneva, Geneva, Switzerland)
13:00 – 14:30   Lunch at the Restaurant of the University
Session 4: "OMICS" of protein phosphatases
Chair: Anna Castro
14:30 – 14:55 IT8 New approaches to decipher the PP1 substratome
Maja Köhn (University of Freiburg, Germany)
14:55 – 15:20 IT9 Anchoring signaling in space: a proximity map of a human cell
Anne-Claude Gingras (Lunenfeld-Tanenbaum Research Institute, Toronto, Canada)
15:20 – 15:45 IT10 CRISPR-genomic base editing and global phosphoproteomics provide insights into the actions of de novo missence variants of PPP2R5D
Richard Honkanen (University of South Alabama, Mobile, United States)
15:45 – 16:00 ST2 Effects of carboxyl-terminal methylation on PP2A, PP4 and PP6 holoenzyme function
Arminja Kettenbach (Dartmouth-Hitchcock Medical Center, Hanover, United States)
Session 5: Industrial Talk

16:00 – 16:25


When screening matters
Piotr Wardęga (NanoTemper Technologies sp. z o.o., Krakow, Poland)

Free afternoon

19:00 –   Dinner at the “Régi Vigadó” Restaurant

Day 3 - Thursday, 13 June 2019

Session 6: Targeting protein phosphatases in cancer
Chair: Veerle Janssens
9:00 – 9:25 IT11 Modulation of oncogenic signalling by dual-specificity map kinase phosphatases
Stephen Keyse (University of Dundee, Dundee, United Kingdom)
9:25 – 9:50 IT12 Dynamic regulation of MYC’s oncogenic activity through reversible phosphorylation
Rosalie Sears (Oregon Health and Science University, Portland, United States)
9:50 – 10:05 ST3 Linking CDCA2/PP1 to Myc in neuroblastoma and triple negative breast cancer
Paola Vagnarelli (Brunel University, London, United Kingdom)
10:05 – 10:30 IT13 Pp2a deregulation in cancer initiation and therapy
Jukka Westermarck (University of Turku, Finland)
10:30 – 11:10   Coffee Break
11:10 – 11:35 IT14 Targeting SHP2 in cancer
Benjamin Neel (NYU Langone Medical Center, New York, United States)
11:35 – 12:00 IT15 Role of protein tyrosine phosphatase 1B (PTP1B) in the immune system
Mirela Delibegovic (University of Aberdeen, United Kingdom)
12:00 – 12:15 ST4 Cell signaling by homophilic receptor tyrosine phosphatases
Hayley Sharpe (Cambridge Institute for Medical Research, United Kingdom)
12:15 – 12:30 ST5 A role for the inducible dual-specificity phosphatase 2 (DUSP2) in regulation of oncogenic signalling in haematological cancer
Henrike Bruckmüller (The Arctic University of Norway, Tromsø, Norway)
12:30 – 12:45 ST6 Function of phosphoprotein phosphatase 6 as a suppressor gene for skin carcinogenesis
Hiroshi Shima (Miyagi Cancer Center research Institute, Miyagi, Japan)
13:00 – 14:30   Meet the Expert Lunch
Lecturers will be dedicated to small group conversation - first come first served basis
Session 7: Protein phosphatases in cell cycle regulation
Chair: Mirela Delibegovic
14:30 – 14:55 IT16 The Two PP2A-B55 inhibitors ARPP19 and ensa differentially control cell cycle progression and embryonic development
Anna Castro (CRBM, Montpellier, France)
14:55 – 15:10 ST7 How Arpp19 controls the switch between Cdk1 and PP2A-B55 at both mitotic entry and upon mitotic exit
Thierry Lorca (Montpellier University, France)
15:10 – 15:25 ST8 PP1 and PP2A use opposite phospho-dependencies to control distinct processes at the kinetochore
Richard John Smith (University of Dundee, United Kingdom)
15:25 – 15:40 ST9 PP1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing
Margarida Moura (University of Porto, Portugal)
15:40 – 16:30   Coffee Break and Group photo
Open Forum: How to increase your visibility
Moderated by Edit Görögh
16:30 – 16:50   Navigating the world of open science: alternative ways of dissemination and impact measurement to increase visibility
Edit Görögh (University of Debrecen, Hungary)
17:00 – 17:30  Panel1 How to publish in scientific papers
Life Science Building 003-004
Wolfgang Peti (University of Arizona, Tucson, United States)
Edit Görögh (University of Debrecen, Hungary) 
17:00 – 17:30  Panel2 Grant writing, submission and review process
Life Science Building 007-008
Richard Honkanen (University of South Alabama, United States)
Antja Gohla (University of Wurzburg, Germany)
17:00 – 17:30  Panel3 Keys to being a successful mentor
Life Science Building F301 seminar room
Martha Cyert (University of Stanford, IUBMB)
Ferenc Erdődi (University of Debrecen, Hungary)
17:00 – 17:30  Panel4 Transition from postdoc to PI
Life Science Building F401 seminar room
Maja Köhn (University of Freiburg, Germany)
Jakob Nilsson (University of Kentucky, United States)
Session 8: Poster Session – Wine and cheese party
17:30 – 21:00  

Poster Session

List of posters

Day 4 - Friday, 14 June 2019

Session 9: Network analysis of signaling and disease
Chair: Yotis Senis
9:00 – 9:25 IT17 Zebrafish with Noonan Syndrome develop myeloproliferative disease
Jeroen den Hertog (University of Leiden, The Netherlands)
9:25 – 9:50 IT18 Targeting hypothalamic PTPs to combat obesity
Tony Tiganis (Monash University, Melbourne, Australia)
9:50 – 10:05 ST10 A role for PP2A in connecting cell metabolism with the DNA damage response
Elisa Ferrari (Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy)
10:05 – 10:30 IT19 The inhibitory receptor G6b-B, macrothrombocytopenia and myelofibrosis
Yotis Senis (University of Birmingham, Birmingham, United Kingdom)
10:30 – 10:40 Business Meeting - Voting for the organiser of 2023 Europhosphatase meeting
10:40 – 11:10   Coffee Break
11:10 – 11:35 IT20 Using IPSCS to delineate the PTPN11-associated gastrointestinal difficulties in rasopathy patients
Maria Kontharidis (Harvard Medical School, MA, United States)
11:35 – 12:00 IT21 Towards understanding the tumor suppressor function of PP2A-B56
Jakob Nilssen (University of Kopenhagen, Denmark)
12:00 – 12:25 IT22 Role of tyrosine phosphatases in rheumatoid synoviocytes
Nunzio Bottini (University of California San Diego, CA, United States)
12:25 – 12:40 ST11 Inflammation-induced epidermal hyperplasia upon deletion of the phosphatase regulator NIPP1 in keratinocytes
Aleyde Van Eynde (Katholieke Universiteit Leuven, Belgium)
12:40 – 12:55 ST12
Interplay between the tyrosine kinases Chk, Csk and phosphatase CD148 is critical for regulating platelet homeostasis
Zoltan Nagy (University of Birmingham, United Kingdom)
13:00 – 14:00   Lunch at the Restaurant of the University
14:00 – 22:00
  Hortobágy Tour 18:00 Dinner at the Hortobágy Csárda

Day 5 - Saturday, 15 June 2019

Session 10: Protein phosphatases in neurodegenerative diseases
Chair: Sheila Harroch
9:00 – 9:25 IT23 Phosphatases and kinases unbalance in acute and chronic neurodegeneration
Teresa Iglesias (CSIC and CIBERNED, Madrid, Spain)
9:25 – 9:50 IT24 Selective inhibition of phosphatases to treat neurodegenerative diseases
Anne Bertolotti (Medical Research Council, Cambridge, United Kingdom)
9:50 – 10:15 IT25 Phosphotyrosine phosphatases in Alzheimer disease
Odete da Cruz E. Silva (University of Aveiro, Portugal)
10:15 – 10:40 IT26 Cell signaling diseases characterized by PP2A dysfunction
Veerle Janssens (Katholieke Universiteit Leuven, Belgium)
10:40 – 11:10   Coffee Break
Session 11: Signaling pathways of non-canonical phosphatases
Chair: Antje Gohla
11:10 – 11:35 IT27 Novel insights into phosphoglycolate phosphatase function and inhibition 
Antje Gohla (University of Wuerzburg, Wuerzburg, Germany)
11:35 – 12:00 IT28 PHLPP1 counter-regulates Stat1-mediated inflammatory signaling
Alexandra Newton (University of California San Diego, CA, United States)
12:00 – 12:15 ST13 Changes to positional dynamic of protein phosphatases regulate cell differentiation during trypanosome transmision
Balazs Szoor (University of Edinburgh, United Kingdom)
12:15 – 12:40 IT29 Molecular bases of the extreme toxicity of fungal phosphatase PPZ1
Joaquín Ariño (Universitat Autònoma de Barcelona, Spain)
12:40 – 12:55 ST14 Targeting glioblastoma through the inhibition of human Scps, a family of HAD phosphatases
Jessie Zhang (University of Texas, Austin, United States)
13:00 – 14:30   Lunch at the Restaurant of the University
Session 12: Protein phosphatases as therapeutic targets
Chair: Nunzio Bottini
14:30 – 14:55 IT30 Structure, function, and therapeutic targeting of oncogenic phosphatases
Zhong-Yin Zhang (Purdue University, West Lafayette,United States)
14:55 – 15:10 ST15 Next generation cell active inhibitors of PTP4A3 phosphatase
John Lazo (University of Virginia, United States)
15:10 – 15:35 IT31 Protein tyrosine phosphatases: basic research to new therapeutics
Nick Tonks (Cold Spring Harbor Laboratory, Long Island, United States)
15:35 – 16:00 IT32 Targeting PIM 3 and DAPK3 Regulating Myosin Phosphatase to Control Hypertension
Timothy Haystead (Duke University Medical School, NC, United States)
16:00 – 16:30   Coffee Break
Session 13: Keynote Lecture
Chair: Ferenc Erdődi
16:30 – 17:30 KL2 Protein Phosphatase PP1: The Awakening of a Sleeping Beauty'
Mathieu Bollen (Katholieke Universiteit Leuven, Belgium)
17:30 –   Closing Remarks
László Csernoch - Vice Rector of the University of Debrecen
Beáta Lontay - Europhosphatase 2019
INVITATION to Europhosphatase 2021
Yotis Senis, main organizer
19:30 – 00:00   Gala Dinner at the Divinus Restaurant

Day 6 - Sunday, 16 June 2019

10:00 –   Departure from Debrecen
    Budapest Tour - Facultative

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